NAD+ (Nicotinamide adenine dinucleotide) is an essential molecule in our body that plays a crucial role in energy metabolism, DNA repair, and cell recovery. As we age, the levels of NAD+ in our body decrease, which can contribute to aging and a decline in energy and vitality. Fortunately, there are various NAD+ precursors available that help us support the production of this vital molecule. But what is the best NAD+ precursor? In this article, we compare the four main precursors: NMN, NR, NA, and Trp.
What is NAD+ and why does our body need it?
NAD+ is a coenzyme that is essential for the functioning of many enzymes in the body. It plays an important role in energy production within cells by helping to convert nutrients into energy. NAD+ is also involved in DNA repair and regulating important cellular functions. It is often associated with aging processes, as a decrease in NAD+ can lead to reduced cell function and increased signs of aging.
The importance of NAD+ supplementation as we age
As we age, the amount of NAD+ in our body decreases, which affects our energy levels, cellular health, and overall rejuvenation. Supplementing NAD+ by using NAD+ precursors can help compensate for the decline of NAD+ and maintain its benefits for our energy and health. However, not all precursors are equal – the effectiveness of an NAD+ precursor depends on how well it is converted into NAD+ in the body. This is where the choice between different precursors such as NMN, NR, NA, and Trp becomes important.
Overview of NAD+ Precursors: NMN, NR, NA, and Trp
There are four popular NAD+ precursors, each with their own unique properties and benefits:
- NMN (Nicotinamide Mononucleotide): What is NMN? NMN is a direct precursor of NAD+. It is particularly effective because it can be quickly absorbed by the cells and directly converted into NAD+ via the salvage pathway, making it an excellent choice for increasing NAD+ levels.
- NR (Nicotinamide Riboside): NR is another well-known NAD+ precursor, but it must first be converted into NMN before it can increase NAD+. This makes the conversion slightly more complex compared to NMN, which may lead to slightly lower effectiveness.
- NA (Nicotinezuur): NA is a vitamin B3 derivative that can also contribute to increasing NAD+ levels. However, it is less directly effective than NMN and NR and can cause side effects such as a "flushing" sensation in some people.
- Trp (Tryptophan): Tryptophan is an essential amino acid that can contribute in small amounts to NAD+ production via the tryptophan-bound pathway. However, it is a less direct precursor and requires more enzymatic steps to increase NAD+.
Effectiveness and benefits of each precursor

Let's examine the effectiveness of each precursor in more detail:
- NMN: NMN offers excellent benefits by being quickly absorbed in the body and directly converted into NAD+ via the salvage pathway. This makes it particularly effective for rapidly increasing NAD+ levels. It supports cell health, energy levels, and has potential for anti-aging effects.
- NR: NR is a well-known NAD+ precursor, but it is first converted into NMN before it changes into NAD+. This means it has a longer conversion pathway, which can result in a slower increase in NAD+ levels. Nevertheless, it offers benefits such as increased energy and enhancement of cellular functions.
- NA: Although NA can also help increase NAD+, it is less effective than NMN and NR because it must be converted via a different pathway. However, it does have benefits for heart health and can help lower cholesterol.
- Trp: Tryptophan contributes to NAD+ via the tryptophan-bound pathway, but the conversion is much less efficient than with NMN. However, Trp has other health benefits such as promoting serotonin production, which is good for mood and sleep.
Comparison of bioavailability and stability
The bioavailability and stability of NMN make it a strong choice for the increasing NAD+ levels. NMN is quickly absorbed by the cells and immediately increases NAD+ levels, while NR first needs to be converted into NMN, which slightly reduces its effectiveness. Additionally, NMN is well tolerated without many side effects, while NA can cause skin reactions in some people and Trp is less effective in increasing NAD+.
Availability and market demand of NAD+ precursors
Currently, NMN is the most popular NAD+ precursor on the market. This is because it offers a direct and efficient way to increase NAD+. Moreover, NMN is readily available, and there are many products that contain this precursor. NR has faced patent issues, which can affect the availability of certain products. NA and Trp are less popular for NAD+ supplementation.
but can still offer benefits for specific health applications.
Recommendation: Why Choose NMN Products from Enduravita?
At EnduraVita, we offer high-quality NMN supplements designed for maximum absorption and effectiveness. Our NMN products are carefully formulated to help you boost your energy, improve cell functions, and combat the signs of aging. The benefits of NMN from EnduraVita include:
- Fast absorption for a direct increase of NAD+.
- High stability, ensuring an effective dose with every intake.
- Ease of use, with clear dosage instructions and high-quality capsules for daily supplementation.
Our NMN products are ideal for people looking for an anti-aging solution or who want to improve their energy and cell health. If you are looking for the best NAD+ precursor, NMN is the most efficient choice. It offers the fastest and most direct increase in NAD+ levels, resulting in improved energy, cell function, and anti-aging benefits. EnduraVita’s NMN products offer the highest quality, so you can benefit from the many health advantages of this powerful precursor. So buy NMN at EnduraVita!